J Anesth Perioper Med. 2017;4(3):123-128. https://doi.org/10.24015/ebcmed.japm.2017.0027

Carbamylated Erythropoietin and Its Role of Tissue Protection

Hao Li1,2, Min Diao1,2, Yu-Shan Ma1,2, and Xue-Mei Lin1,2

From 1Department of Anesthesiology, West China Second University Hospital, Sichuan University, Chengdu, China; 2Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.

Correspondence to Dr. Xue-Mei Lin at xuemeilinscu@163.com.

EBCMED ID: ebcmed.japm.2017.0027 DOI: 10.24015/ebcmed.japm.2017.0027


Aim of review
We reviewed the study of carbamylated erythropoietin (CEPO) and its probable mechanism involved in the regulation of tissue-protection.

Recent published literatures in this area were inclusive and reviewed.

Recent findings
CEPO has equivalent tissue-protective properties as recombinant human erythropoietin (rhEPO) but with non-erythropoietic effects. It shows protective properties on nervous system, heart, kidney and some other organs, which are associated with inhibition of apoptosis, restoration of vascular autoregulation and attenuation of inflammatory responses. However, the underlying mechanism of CEPO responsible for its beneficial effects is still not well-known.

CEPO gradually turned into a promising drug candidate at least for many diseases caused by ischemia reperfusion injury. The safety and efficacy of CEPO in clinical are warranted in the future.

Article Type
Review Article

Declaration of Interests
All authors have no conflicts of interest to declare for this work.

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