J Anesth Perioper Med. 2017;4(1):1-6. https://doi.org/10.24015/ebcmed.japm.2017.0001
From 1Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China; 2Department of Anesthesiology, Air Force General Hospital of the Chinese PLA, Beijing, China.
*Contributed equally to this work.
Correspondence to Dr. Wei-Feng Yu at email@example.com.
EBCMED ID: ebcmed.japm.2017.0001 DOI: 10.24015/ebcmed.japm.2017.0001
In this study, the effects of sevoflurane or propofol on immune function in patients undergoing partial hepatectomy were investigated during general anesthesia and after surgery.
Seventy-two patients undergoing hepatectomy were randomized into sevoflurane group or propofol group. Sevoflurane or target-controlled infusion (TCI) of propofol was separately used to anesthesia induction and maintenance of two groups. Venous blood samples were taken before induction, 2 hours after anesthesia and 2 hours after surgery for measurement of the percentages of T lymphocyte (CD3+, CD4+, CD8+) and NK cells.
Compared with that before anesthesia induction, percentage change in CD3+ and CD4+ T cells to baseline was -0.7% and 3.8% in sevoflurane group, 10.2% and 20.2% in propofol group 2 hours after anesthesia (P=0.002 for CD3+ T cells and P=0.029 for CD4+ T cells ). Percentage change in NK cells was 17.6% in sevoflurane and -12.2% in propofol group 2 hours after anesthesia respectively (P=0.03). There was no significant difference in percentage change 2 hours after surgery of T cells and NK cells to baseline between two groups.
Our study indicates that use of propofol during general anesthesia tend to increase the percentages of peripheral CD3+ and CD4+ cells, while sevoflurane increase the peripheral NK cells.
Declaration of Interests
All authors have no other potential conflicts of interest for this study to declare.
This study was supported by a grant from the National Natural Science Foundation of China: (NSFC, No.81371511 and No.31171013).
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