J Anesth Perioper Med. 2015;2(1):29-35. https://doi.org/10.24015/ebcmed.japm.2015.0005

The Role of Emulsified Isoflurane in Multi-Organ Protection

Zhao-Yang Hu, and Jin Liu

From the Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China.

Correspondence to Dr. Jin Liu at scuanesth@hotmail.com.

EBCMED ID: ebcmed.japm.2015.0005 DOI: 10.24015/ebcmed.japm.2015.0005


Aim of review
This review describes the multi-organ protective effects of emulsified isoflurane.

This review examines the recent experimental researches involving emulsified isoflurane-induced preconditioning and postconditioning in multiple organs.

Recent findings
Emulsified isoflurane is a new formulation of isoflurane in lipid emulsion. It enables an intravenous, intraperitoneal injection or oral (rather than the traditional inhalation) route of administration for this anesthetic. Pharmacological preconditioning and postconditioning by using inhalation isoflurane have been demonstrated to be the protective strategies in clinical settings for the high risk patients with various organ dysfunctions. In recent years, there has been increased interest in exploring the protective effect of emulsified isoflurane in multiple organs including heart, brain, kidney, liver and lung, providing potential approaches translating these convincing experimental conditioning effects to clinical practice.

Emulsified isoflurane could exert strong organ-protective effects. With an understanding of its potential mechanisms, therapeutic approaches may be applied to the future organ-protective properties, transferring convincing experimental evidences into clinical therapies.

Article Type
Review Article

Declaration of Interests
No other potential conflicts of interest relevant to this review was reported.

This study was supported by Grant No. 30901412 from the National Natural Science Foundation of China.

This is an open-access article, published by Evidence Based Communications (EBC). This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium or format for any lawful purpose. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.