J Anesth Perioper Med. 2014;1(2):122-124. https://doi.org/10.24015/ebcmed.japm.2014.0018

Surgery, Neuroinflammation and Long-Term Outcome

Monty Lyman, and Da-Qing Ma

From Section of Anaesthetics, Pain Medicine & Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, UK.

Correspondence to Dr. Da-Qing Ma at d.ma@imperial.ac.uk.

EBCMED ID: ebcmed.japm.2014.0018 DOI: 10.24015/ebcmed.japm.2014.0018


Tissue damage caused by surgery invokes an inflammatory response that is often amplified from local to systemic. Research into the associations between surgery and the onset of neurodegenerative diseases and elucidation of many inflammatory pathways in the brain is just beginning. Nevertheless, in order to protect patients with existing pathologies and prevent surgery increasing the risk of developing dementia in asymptomatic patients, perioperative care research must look for ways of attenuating surgery-induced neuroinflammation.

Article Type

Declaration of Interests
No potential conflict of interest relevant to this opinion was reported.

This is an open-access article, published by Evidence Based Communications (EBC). This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium or format for any lawful purpose. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.