J Anesth Perioper Med. 2014;1(1):44-49. https://doi.org/10.24015/ebcmed.japm.2014.0007

Neuroendocrine-Immune Interaction in Lung Diseases

Jing Lin1, Lei Du1, and Jerry Yu2

From the 1Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China; 2Department of Pulmonary Medicine, University of Louisville, and Robley Rex VA Medical Center, Louisville, USA.

Correspondence to Dr. Jerry Yu at j0yu0001@louisville.edu.

EBCMED ID: ebcmed.japm.2014.0007 DOI: 10.24015/ebcmed.japm.2014.0007


Aim of review
This overview describes neuroendocrine immune regulation of inflammation in the lung.

The articles published in past 2 decades in this area were reviewed.

Recent findings
Pulmonary diseases are often associated with inflammation, which is an essential body response to infection and injury. During inflammation, various cells are activated to release inflammatory molecules, modulating disease progression. Inflammation is regulated by the immune system, which interacts with the neuroendocrine system via the autonomic nerves and the hypothalamic- pituitary- adrenal axis. During lung diseases airway sensors are activated to produce host defense responses against inflammation, infection and trauma.

These neural-mediated responses are immediate and non- specific. They may amplify inflammation via local or axonal reflexes to enhance immune protection or suppress inflammation via the central nervous system to avoid tissue destruction.

Article Type
Review Article

Declaration of Interests
All authors have no financial support and potential conflicts of interest for this work.

This work was supported by a VA Merit Review Award (PULM-029-10S).

This is an open-access article, published by Evidence Based Communications (EBC). This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium or format for any lawful purpose. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.